Paramedic PapersHome Cardiac arrest Three post-ROSC lab phenotypes predict outcome
Cardiac arrest
Three post-ROSC lab phenotypes predict outcome
Early Post-ROSC Laboratory Phenotypes and Clinical Outcomes after Out-of-Hospital Cardiac Arrest: A 10-Year National Cohort Study
Resuscitation · 2026-10 · Added 11 October 2026
Latent class analysis of 14 laboratory values drawn within six hours of ROSC in 1,514 resuscitated OHCA patients identified three phenotypes, with the multi-organ dysfunction group at roughly double the odds of poor neurological recovery compared with the others.
- Study type
- Registry
- Design
- Retrospective national registry cohort with latent class analysis
- Participants
- 1,514 resuscitated adults with presumed cardiac OHCA
- Main finding
- Multi-organ dysfunction phenotype had higher odds of poor neurological recovery versus homeostatic (aOR 0.50, 95% CI 0.30–0.78) and immune-dysregulated (aOR 0.46, 95% CI 0.26–0.78) phenotypes, with mortality differences persisting to 3 years
- Caveat
- Exploratory derivation study from a single country's database, awaiting external validation before guiding therapy
- Bottom line
- Hypothesis-generating
Why it matters in Australia (Medium relevance). Phenotyping depends on in-hospital bloods taken within six hours of ROSC, so this shapes post-arrest care pathways and handover conversations more than anything done roadside.
Learning goal
Recognise how early post-ROSC laboratory patterns may identify cardiac arrest patients at risk of poor neurological recovery.
More
- Topic: Cardiac arrest
- Daily scan: 11 October 2026
- Podcast: Paramedic Papers Daily, 11 October 2026
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