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Prehospital antibiotics earlier in sepsis

Association Between Early Prehospital Administration Antibiotic and 28-Day Mortality in Sepsis
Prehospital Emergency Care · Added 22 September 2026

Thai observational cohort of 364 adults with suspected sepsis testing prehospital antibiotics — prehospital administration was associated with lower adjusted 28-day mortality (ARR 8.9%, 95% CI 0.8–17.1; aOR 0.51) and antibiotics ~125 minutes sooner, but scene times ran 8.5 minutes longer.

Study type

Cohort

Design

Single-centre observational cohort

Participants

364 adults with suspected sepsis

Main finding

Prehospital antibiotics (154/364) associated with lower 28-day mortality (25.9% vs 28.1%; adjusted ARR 8.9%, 95% CI 0.8–17.1; aOR 0.51) and antibiotics given ~125 minutes sooner, at the cost of ~8.5 minutes longer scene time

Caveat

Single-centre observational design; residual confounding likely despite adjustment

Bottom line

Hypothesis-generating

Learning goal

Weigh the survival benefit of prehospital antibiotics in sepsis against the added scene time before hospital arrival.

More

• Topic: Sepsis & infection
• Daily scan: 22 September 2026

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