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Cardiac arrest

Individualised MAP targets after OHCA (protocol)

Neuroprotection via optimizing cerebral blood flow after cardiac arrest (neuro-intact) study – A phase II proof-of-concept study protocol
Resuscitation Plus · Added 6 August 2026

Phase II protocol testing whether individualised MAP targets derived from real-time cerebral autoregulation monitoring reduce secondary brain injury after cardiac arrest — this proof-of-concept trial uses near-infrared spectroscopy and transcranial Doppler to identify each patient's optimal MAP rather than applying uniform targets.

Study type

RCT

Design

Phase II single-arm proof-of-concept trial protocol using NIRS and transcranial Doppler to derive individualised optimal MAP

Participants

49 comatose OHCA survivors within 12 h of ROSC

Caveat

Protocol only, no results; single-centre, single-arm, surrogate endpoints

Bottom line

Hypothesis-generating

Learning goal

Update my approach to blood pressure targets after resuscitation from out-of-hospital cardiac arrest.

More

• Topic: Cardiac arrest
• Daily scan: 6 August 2026

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