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Multi-domain post-arrest prognostication data feasibility

Feasibility of multi-domain data acquisition in patients at risk for hypoxic-ischemic brain injury following cardiac arrest: a prospective cohort study
Resuscitation Plus · Added 20 September 2026

Canadian prospective feasibility study testing whether multi-domain prognostication data (biomarkers, transcranial Doppler, EEG, neuroimaging, six-month outcomes) can be collected in 30 adults after cardiac arrest — day-1 biomarkers (97%) and CT/MRI were feasible, but serial transcranial Doppler (77%), day-7 biomarker sampling (71%) and the complete six-month multidomain battery (33%) fell short, with remote or proxy-assisted follow-up improving outcome ascertainment.

Study type

Cohort

Design

Prospective feasibility cohort study

Participants

30 adults admitted to critical care after cardiac arrest

Main finding

Day-1 biomarkers obtained in 97%, CT/MRI in 100%; but transcranial Doppler in 77%, day-7 biomarkers in 71%, and complete six-month in-person multidomain battery in 4/12 (33%) hospital survivors; remote or proxy-assisted follow-up improved outcome ascertainment.

Caveat

Small single-centre feasibility sample; no outcome conclusions.

Bottom line

Hypothesis-generating

Learning goal

Understand how multi-domain prognostic data after cardiac arrest can be gathered feasibly to inform neurological outcome discussions.

More

• Topic: Cardiac arrest
• Daily scan: 20 September 2026

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