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Cardiac arrest

TANGO2: compression-only vs standard bystander CPR

Design and rationale of the TANGO2 trial: A randomized controlled non-inferiority trial of bystander compression-only CPR versus standard CPR in out-of-hospital cardiac arrest
American Heart Journal · 2026-10-06 · Added 8 October 2026

Protocol for TANGO2, a Swedish-Italian dispatcher-randomised non-inferiority trial testing whether bystander compression-only CPR is non-inferior to standard CPR for 30-day survival in ~3,260 dispatch-assisted OHCA patients.

Study type

RCT

Design

Randomised controlled non-inferiority trial protocol (dispatcher-randomised, open-label)

Participants

Estimated 3,260 per-protocol EMS-treated OHCA patients

Main finding

No results yet — enrolment since 2017, estimated completion December 2027; non-inferiority margin set at an absolute risk difference of −1.0 percentage point

Caveat

Protocol only — no outcome data; open-label design with adherence assessed from dispatch audio

Bottom line

Context only

Learning goal

Weigh the evidence for dispatcher-assisted compression-only CPR against standard CPR when advising bystanders in out-of-hospital cardiac arrest.

More

• Topic: Cardiac arrest
• Daily scan: 8 October 2026

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