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Obstetrics
Low HDFN risk after prehospital RhD-positive blood
Rate of future hemolytic disease of the fetus and newborn following the prehospital transfusion of RhD-positive blood products to females of childbearing potential in the United States of America
Prehospital Emergency Care · Added 1 September 2026
In silico simulation modelling future haemolytic disease of the fetus and newborn risk in 957 US females of childbearing potential who received prehospital RhD-positive blood — annual HDFN risk ranged 0.214–0.294% across regions
- Study type
- Modelling
- Design
- In silico simulation modelling
- Participants
- 957 US females of childbearing potential transfused prehospital with RhD-positive products over ~5 years; 19.5 million simulated FCPs
- Main finding
- Annual future HDFN risk ranged 0.214% (Northeast) to 0.294% (South); 1,368 cases over the 2,500-year simulation (0.55/year), i.e. one case every ~2.4–80.7 years by region
- Caveat
- Modelled estimates reliant on assumptions about nativity, age distribution and future pregnancy rates
- Bottom line
- Supports current practice
Why it matters in Australia (Medium relevance). transferability — Not in the ACTAS formulary — blood products are not carried, but important safety consideration if ACTAS ever adopts prehospital blood
Learning goal
Weigh the future haemolytic disease risk when transfusing RhD-positive blood to females of childbearing potential prehospital.
More
- Topic: Obstetrics
- Daily scan: 1 September 2026
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