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Cardiac arrest
Kidney biomarkers predict outcomes after OHCA
Prognostic performance of plasma and urinary biomarkers of kidney injury and function after out-of-hospital cardiac arrest
Resuscitation · Added 25 August 2026
Prospective study of 82 comatose OHCA patients found kidney-specific biomarkers (plasma and urinary NGAL and KIM-1, cystatin C) were superior to serum creatinine for early AKI detection and prediction of poor neurological outcomes at discharge.
- Study type
- Cohort
- Design
- Prospective observational biomarker study
- Participants
- 82 comatose adults with OHCA
- Main finding
- Kidney-specific biomarkers (plasma and urinary NGAL, KIM-1, cystatin C) outperformed serum creatinine for early AKI detection and predicting poor neurological outcome; AKI in 65.9%, CPC 3–5 in 54.9%
- Caveat
- Small single-cohort observational study; biomarkers measured post-ROSC, limited relevance to prehospital care
- Bottom line
- Context only
Why it matters in Australia (Medium relevance). Hospital-based biomarker research — relevant for post-arrest care but not prehospital decision-making
Learning goal
Build my understanding of how kidney injury after out-of-hospital cardiac arrest influences post-ROSC care and prognostic conversations.
More
- Topic: Cardiac arrest
- Daily scan: 25 August 2026
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