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Cardiac arrest

DSED use rising but still low after DOSE VF

Use of double sequential external defibrillation in the United States before and after the DOSE VF randomized clinical trial
Prehospital Emergency Care · Added 18 May 2026

Nationwide observational study examined trends in DSED use for refractory VF before and after publication of the DOSE VF trial.

Study type

Cohort

Design

Retrospective interrupted time-series analysis of a national EMS data collaborative

Participants

16,450 adults with OHCA and VF/pVT and ≥4 defibrillation attempts from 906 agencies, 2018–2024

Main finding

DSED use varied by identification method (1.8%–7.6%); use detected by any method increased after DOSE VF publication (7.3% vs 8.2%, p=0.048), with a rate increase of RR 1.09 (95% CI 1.04–1.14) per quarter.

Caveat

DSED identified by proxy measures with potential misclassification; observational design cannot link use to outcomes.

Bottom line

Context only

Learning goal

Weigh the emerging evidence for double sequential defibrillation in refractory ventricular fibrillation cardiac arrest.

More

• Topic: Cardiac arrest
• Daily scan: 18 May 2026

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