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LVOT VTI unreliable for mild hypovolaemia

Changes in LVOT velocity–time integral during whole blood donation: implications for early detection of hypovolemia in spontaneously breathing patients
Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine · Added 8 September 2026

Prospective study measuring LVOT VTI in 63 volunteers before and after donating about 6–7 mL/kg of blood — VTI fell 11.5% on average but with marked inter-individual variability, so it can't reliably flag mild hypovolaemia on its own.

Study type

Other

Design

Prospective physiological study of volunteers before and after blood donation

Participants

63 healthy adult volunteers donating ~6-7 mL/kg blood

Main finding

LVOT VTI fell 11.5% (95% CI -15.3 to -7.7) immediately after donation and remained 6.1% below baseline at 15 minutes; a ≥10% reduction occurred in only 50% (95% CI 37-63) of participants

Caveat

Healthy volunteers with controlled donation, not actual patients; marked inter-individual variability

Bottom line

Hypothesis-generating

Learning goal

Weigh the value of point-of-care ultrasound measures like LVOT VTI when assessing suspected early hypovolaemia.

More

• Topic: Trauma
• Daily scan: 8 September 2026

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