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Transport ventilation during CPR feasible in pilot

Transport mechanical ventilation during cardiopulmonary resuscitation in out-of-hospital cardiac arrest: an exploratory prehospital pilot study
BMC Emergency Medicine · 2026-07-29 · Added 28 October 2026

A Thai exploratory pilot compared transport mechanical ventilation (HAMILTON-T1, volume-controlled) with bag-valve ventilation during CPR in adult OHCA and found no significant differences in PCO2, pH, pO2, sustained ROSC or 28-day survival, with mechanical ventilation operationally feasible.

Study type
Other
Design
Prospective, time-sequenced exploratory pilot (6 months bag-valve, then mechanical ventilation)
Participants
41 adults with OHCA (29 bag-valve, 12 mechanical ventilation)
Main finding
No significant differences in PCO2, pH or pO2, sustained ROSC or 28-day survival between groups; mechanical ventilation feasible despite implementation challenges
Caveat
Exploratory pilot, not powered for clinical outcomes, and the unequal groups (29 vs 12) were sequential rather than randomised
Bottom line
Hypothesis-generating

Why it matters in Australia (Medium relevance). Transport ventilators for ongoing CPR are a critical care capability rather than standard kit on most Australian ambulances, and drug-assisted intubation is an intensive care paramedic skill in most services — but this is exactly the crew the findings speak to.

Learning goal

Weigh the benefits and practical challenges of mechanical ventilation during transport CPR in adult cardiac arrest.

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