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Cardiac arrest

Post-arrest biomarker platforms don't agree

Quantification of blood-based neurovascular unit biomarkers: an analytical platform comparison study
Resuscitation Plus · Added 22 September 2026

Platform-comparison study of post-arrest HIBI biomarkers (GFAP, Nf-L, tau, UCH-L1) — lab-grade analyser results correlated highly with each other, but the point-of-care i-STAT agreed poorly, so prognostication thresholds can't be shared across devices

Study type

Cohort

Design

Post hoc cross-platform analytical comparison within a prospective observational cohort

Participants

32 critically ill patients after withdrawal of life-sustaining therapy

Main finding

GFAP, Nf-L, tau and UCH-L1 highly correlated between Simoa HD-X and ARGO HT (all r ≥ 0.97), but i-STAT Alinity agreement was poor-to-moderate for GFAP (ICC 0.25) and poor-to-good for UCH-L1 (ICC 0.60)

Caveat

Small sample and post hoc design; not a clinical outcome study

Bottom line

Context only

Learning goal

Weigh the reliability of point-of-care biomarkers for neurological prognostication after cardiac arrest.

More

• Topic: Cardiac arrest
• Daily scan: 22 September 2026

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