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Paediatrics
Post-ROSC PaCO2 doesn't predict paediatric OHCA outcome
Association between the first post-resuscitation partial pressure of arterial carbon dioxide and neurologic outcomes in children with out-of-hospital cardiac arrest: a multicenter retrospective cohort study
Resuscitation · Added 25 September 2026
Japanese multicentre registry study of 215 paediatric OHCA patients testing whether the first post-ROSC PaCO2 category predicts 30-day outcomes — no clear association with favourable neurologic outcome or survival for either hypocapnia (aOR 0.83) or hypercapnia (aOR 1.46), though estimates were imprecise with wide confidence intervals.
- Study type
- Cohort
- Design
- Multicentre retrospective registry cohort with propensity score overlap weighting
- Participants
- 215 children with OHCA (27 hypocapnia, 39 normocapnia, 149 hypercapnia)
- Main finding
- Favourable neurologic outcome at 30 days occurred in 41 (19.1%) and 30-day survival in 92 (42.8%). No clear association between first post-ROSC PaCO2 category and neurologic outcome (hypocapnia aOR 0.83, 95% CI 0.13–5.14; hypercapnia aOR 1.46, 95% CI 0.25–8.68) or survival.
- Caveat
- Small sample with very imprecise estimates (wide confidence intervals)
- Bottom line
- Hypothesis-generating
Why it matters in Australia (Medium relevance). Post-ROSC ventilation and monitoring are within ACTAS scope (CMG 4A), but this is a small retrospective cohort that can't settle the target — hypothesis-generating only.
Learning goal
Weigh the evidence for targeting ventilation to avoid hypocapnia during post-ROSC care in paediatric patients.
More
- Topic: Paediatrics
- Daily scan: 25 September 2026
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