Paramedic PapersHome Other Single-dose aminoglycoside AKI risk in CKD
Other
Single-dose aminoglycoside AKI risk in CKD
The Safety of Single Aminoglycoside Dose in Emergency Departments (SAD-ED) Among Patients With and Without Chronic Kidney Disease: A Retrospective Cohort Study
Emergency Medicine Australasia · Added 4 August 2026
Retrospective cohort across four Australian hospitals — single-dose aminoglycosides caused AKI in 30.9% of CKD patients vs 13.4% without CKD (OR 2.88)
- Study type
- Cohort
- Design
- Retrospective cohort at four Australian tertiary hospitals
- Participants
- 660 ED patients who received single-dose aminoglycosides
- Main finding
- AKI within 1 week occurred in 30.9% of CKD patients vs 13.4% without CKD (OR 2.88, 95% CI 1.76–4.71); CKD patients had more severe AKI (stage 2: 10.1% vs 2.6%)
- Caveat
- Retrospective design with confounding by indication — CKD patients were older with more comorbidities
- Bottom line
- Hypothesis-generating
Why it matters in Australia (High relevance). transferability — Australian study with direct clinical relevance — gentamicin is commonly given in ED/prehospital settings and CKD patients are at substantially higher risk
Learning goal
Weigh the renal risks of single-dose aminoglycosides in patients with chronic kidney disease before administration.
More
- Topic: Other
- Daily scan: 4 August 2026
Related papers on Other
-
How to write medicolegal statements
Practical guide on the statement types Australian emergency clinicians may be asked to provide for police, coroners and criminal proceedings — they're statements of fact rather than opinion, and structure and clarity matter
-
Chronic liver disease ED presentations in Queensland
CLD‐related ED presentations are increasing and place substantial demand on hospital services in Queensland.
-
Prehospital NEWS predicts death despite low ED triage
Prehospital physiologic instability was associated with increased in-hospital mortality among patients classified as low risk at ED triage.
-
Wearable Doppler ultrasound for prehospital monitoring
They reviewed wearable Doppler ultrasound technology for prehospital haemodynamic monitoring, and found it may detect occult haemodynamic compromise earlier than standard vital signs alone.