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No mortality benefit for prehospital whole blood

Efficacy and safety of prehospital whole blood resuscitation in traumatic haemorrhagic shock a systematic review and meta-analysis
The American Journal of Emergency Medicine · Added 30 July 2026

Systematic review and meta-analysis evaluating outcomes of prehospital whole blood transfusion compared to blood component therapy in traumatic haemorrhagic shock.

Study type

Systematic review

Design

Systematic review and meta-analysis of RCTs

Participants

3 RCTs, 2048 adults with traumatic haemorrhagic shock

Main finding

No significant difference between prehospital whole blood and blood components in 24-h mortality (OR 1.12, 95% CI 0.81-1.55), 28-30-day mortality (OR 1.15, 95% CI 0.90-1.47), massive transfusion or thromboembolism; I2 = 0%

Caveat

Only three trials of limited size and quality

Bottom line

Supports current practice

Learning goal

Weigh the evidence for prehospital whole blood versus component therapy when resuscitating adults in traumatic haemorrhagic shock.

More

• Topic: Trauma
• Daily scan: 30 July 2026

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