Paramedic Papers

Home Cardiac arrest Cost-effectiveness of conservative oxygen post-arrest

Cardiac arrest

Cost-effectiveness of conservative oxygen post-arrest

Conservative versus liberal oxygen therapy in hypoxic ischemic encephalopathy following cardiac arrest: a trial-based cost-effectiveness analysis
Resuscitation Plus · Added 27 July 2026

Conservative oxygen was associated with modest cost savings and small differences in health outcomes, with no clear economic advantage over liberal oxygen.

Study type
RCT
Design
Trial-based cost-effectiveness analysis alongside the LOGICAL RCT
Participants
1,821 critically ill adults with post-cardiac arrest hypoxic ischaemic encephalopathy across 53 ICUs in Australia, NZ and Ireland
Main finding
Conservative oxygen: incremental cost -$1,392 (95% CI -$4,696 to $1,911), favourable functional outcome 38.2% (risk difference -1.5 percentage points, 95% CI -6.1 to 3.2), incremental QALYs -0.002 (95% CI -0.013 to 0.008); no clear economic advantage
Caveat
In-hospital ICU population; health system perspective, cost estimates may not generalise
Bottom line
Supports current practice

Learning goal

Weigh conservative versus liberal oxygen targets when caring for patients after return of spontaneous circulation.

Open in dashboard Read the paper (DOI) PubMed

More

Related papers on Cardiac arrest