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Cardiac arrest
Early sedation after ROSC and outcomes
Sedation early after return of spontaneous circulation and during pre-hospital transport after out-of-hospital cardiac arrest: retrospective analysis of the AfterROSC1 & 2 database
Resuscitation · Added 27 July 2026
The decision of sedation started after ROSC and before ICU admission was associated with a good functional recovery on day 90.
- Study type
- Cohort
- Design
- Retrospective analysis of prospective cohort databases
- Participants
- 1,596 post-OHCA adults; 1,324 sedated pre-ICU
- Main finding
- Favourable day-90 outcome 32.4% vs 11.8% (aOR 2.19, 95% CI 1.31–3.65, p=0.003 after mCAHP and centre adjustment), but not significant after propensity adjustment (1.40, 95% CI 0.70–2.09, p=0.26).
- Caveat
- Residual indication bias — sedation likely withheld from the sickest patients; no causal inference possible
- Bottom line
- Hypothesis-generating
Learning goal
Weigh the benefits and risks of early post-ROSC sedation during prehospital transport.
More
- Topic: Cardiac arrest
- Daily scan: 27 July 2026
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