Home › Stroke & neuro › Overshooting BP targets worsens ICH outcomes

Stroke & neuro

Overshooting BP targets worsens ICH outcomes

Early Intensive Blood Pressure Reduction After Intracerebral Hemorrhage Is Associated With Worse Functional Outcome: The Risk of Overshooting Blood Pressure Goals
Annals of Emergency Medicine · Added 1 May 2026

Retrospective cohort testing whether rapid systolic BP reduction ≤150 mm Hg after spontaneous intracerebral haemorrhage improved outcomes — early target achievement and overshooting <120 mm Hg were associated with worse functional outcome.

Study type

Cohort

Design

Retrospective cohort at two academic EDs

Participants

420 adults with spontaneous intracerebral haemorrhage

Main finding

Achieving systolic BP ≤150 mmHg within 2 hours was associated with worse functional outcome (OR 2.32, 95% CI 1.17–4.57), as was overshooting below 120 mmHg within 6 hours (OR 2.55, 95% CI 1.27–5.13)

Caveat

Retrospective design with possible confounding by haemorrhage severity; in-hospital ED population

Bottom line

Context only

Learning goal

Weigh the risks of over-lowering blood pressure against target achievement when managing spontaneous intracerebral haemorrhage.

More

• Topic: Stroke & neuro
• Daily scan: 1 May 2026

Related papers on Stroke & neuro

• Prehospital magnesium before thrombolysis: no overall benefit

  Journal of Stroke and Cerebrovascular Diseases · 31 Jul 2026 · RCT · Hypothesis-generating

  Secondary analysis testing whether prehospital magnesium sulfate followed by thrombolysis improves 90-day outcomes — feasible and safe but no significant overall clinical benefit, though severe stroke patients (NIHSS >15) showed better outcomes in hypothesis-generating subgroup analysis.

• Over-rapid BP drop worse after ICH

  Annals of Emergency Medicine · 27 Jul 2026 · Cohort · Hypothesis-generating

  Retrospective cohort examining whether rapid systolic BP reduction ≤150 mm Hg after spontaneous intracerebral haemorrhage improved outcomes — early target achievement and overshooting <120 mm Hg were associated with worse functional outcome.

• HEMS dispatch timing matters for LVO stroke thrombectomy

  Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine · 27 Jul 2026 · Modelling · Hypothesis-generating

  The efficacy of endovascular thrombectomy (EVT) for large vessel occlusion (LVO) stroke is highly time-dependent.

• Helicopter + ground transport doubles thrombectomy access

  Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine · 27 Jul 2026 · Modelling · Hypothesis-generating

  A hybrid transportation strategy improved access to MT in a single center study.